Research Ideas  

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Welcome to IBD Partners Research Ideas Page!

In this area you will be able to:

  • Propose, vote on, and discuss research ideas
  • View current studies
  • View published research

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You are an active participant in  IBD Partners research prioritization process! Have you ever had a question about IBD that you wish science could answer? Tell us what research is important to you!

Here, you can submit a research idea to the community, cast your votes, and discuss research ideas proposed by other members. Please make your research question as specific as possible. Other members will vote on your research idea, and we will prioritize research ideas with the most votes.

You are allowed to vote for your own proposed research idea if you want. However, you can only vote for a total of five research ideas. If you have already cast your five votes and an idea you like even more is proposed, you can change your votes at any time to reflect your current preferences.

The research team will review all submitted ideas and provide a response to you and to the community. If your idea leads to an IBD Partners Study, you will have the opportunity to serve as a patient collaborator on the research team for that study.

We encourage you to prioritize the ideas that are most important to you, even if the research team determines that your idea is not a good fit for IBD Partners. We will share ideas labeled “Not a Good Fit” with researchers outside of our network when appropriate. We want to make sure all of your votes count!

Thanks for your participation in this important platform to help the IBD research community understand what research questions are important to patients. We are passionate about finding answers to your questions!

Proposed Idea              

ABO blood types and COVID-19

Many medical studies show a connection to COVID-19 severity and ABO blood types. Will IBD partners start researching this with their members? Does blood type and genetics play a role in COVID-19 and IBD?

Genetics
last activity 12 days ago
0    0
Proposed Idea              

What is unique about the histology and/or immunology of fistulas that limit their response to current immunomodulator therapies?

None of the currently approved or clinical stage immunotherapies for IBD have shown to offer substantive benefits in the improvement or healing of fistulas. This is continues to be a significant gap in the non-surgical treatment of fistulizing disease.

Medications
last activity 26 days ago
1    0
Proposed Idea              

Before the COVID crisis, I ate a restaurant meal a half-dozen times a week. During the lockdown restaurant food is rare. My Crohn's symptoms are much improved. Why? What is the relationship?

Eating in restaurants is an important part of life today. We cannot eat at home for every meal (work, school, travel, friends).

Diet
last activity about 1 month ago
0    0
Proposed Idea              

Does timing of colonoscopy affect ability to accurately diagnose UC new cases and/or flares of disease particularly if scheduled more than a couple of weeks out from onset or resolution of symptoms?

If mucosa is allowed to heal before procedure with biopsies, patient may be told either no dz or inactive dz when in fact tissue has healed in the time it took to get test scheduled and performed leading to under diagnosis or a delayed diagnosis. Should guidelines recommend a shorter timeline to procedure in suspected stable new cases or stable non urgent flares? Some gi docs schedules are booked out months in advance so delays in scheduling are common. If patients are told initially no disease but later symptoms resume, more tests procedures are required to eventually establish diagnosis and start treatment.

Procedures And Testing
last activity about 1 month ago
1    0
Proposed Idea              

Can there be a data study (or is there one in progress) to find out what percentage of people have had to go off of different IBD medications because of contracting COVID and needing to boost immune?

I am very scared that if I contract covid I will have to go off of my medication which I have worked so hard to fit to my disease and help stabilize my symptoms. I believe many others are feeling this way right now.

Medications
last activity about 1 month ago
1    0
Proposed Idea              

What percentage of patients fecal caloprotectin levels do not correlate (well or at all!) with colonoscopy results and for those patients, are there common factors that can be described.

For some patients like myself, fecal caloprotectin levels have been either borderline or normal since my surgery, but on colonoscopy active inflammation is seen (ulcers, erythema) at anastomosis or terminal ileum. It would be good to understand if there are some patients for whom this marker can't really be used to assess for recurrence of disease.

Procedures And Testing
last activity 2 months ago
1    0
Proposed Idea              

Has anyone had experience with Qing Dai also known as Indigo Naturalis?

This is a Chinese herb that may improve inflammation. It pops up on-line as a treatment but no extensive research has been done.

Alternative Therapies
last activity 4 months ago
0    0
Proposed Idea              

Test the effectiveness of anti-fungal medications on Crohn's Disease.

A study by David Underhill in "Cell Host & Microbe" suggests a link between Malassezia in the gut and Crohn's Disease. Crohn's patients had high concentrations of Malassezia on their intestinal walls compared to almost none in healthy patients. Adding this fungus to the gut in mice exacerbated inflammation seen in Crohn's.

Medications
last activity 5 months ago
0    0
Proposed Idea              

Does the use of (prebiotic) inulin and/or fructooligosacharides help maintain or increase the gut barrier? Does it reduce IBD relapse? Is it safe? What is the optimal dosage? Any contraindictions?

If the use of prebiotics reduces the onset of UC (or chrohn's) or decreases relapses, then that would be a health improvement.

Diet
last activity 5 months ago
0    0

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Published Studies VIEW ALL
Trends and Characteristics of Clinical Trials Participation for Inflammatory Bowel Disease in the United States: A Report From IBD Partners

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Diet Low in Red and Processed Meat Does Not Reduce Rate of Crohn’s Disease Flares

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Impact of Obesity on Disease Activity andPatient-Reported Outcomes Measurement InformationSystem (PROMIS) in Inflammatory Bowel Diseases

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Active Studies VIEW ALL
The Effects of Antidepressant Medication and Social Support on Disease Progression in IBD Patients

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Symptom Clusters in Adults with Inflammatory Bowel Disease

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Psychological Factors Associated with Adherence to Oral Treatment in IBD

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