In this area you will be able to:
- Propose, vote on, and discuss research ideas
- View current studies
- View published research
Here, you can submit a research idea to the community, cast your votes, and discuss research ideas proposed by other members. Please make your research question as specific as possible. Other members will vote on your research idea, and we will prioritize research ideas with the most votes.
You are allowed to vote for your own proposed research idea if you want. However, you can only vote for a total of five research ideas. If you have already cast your five votes and an idea you like even more is proposed, you can change your votes at any time to reflect your current preferences.
The research team will review all submitted ideas and provide a response to you and to the community. If your idea leads to an IBD Partners Study, you will have the opportunity to serve as a patient collaborator on the research team for that study.
We encourage you to prioritize the ideas that are most important to you, even if the research team determines that your idea is not a good fit for IBD Partners. We will share ideas labeled “Not a Good Fit” with researchers outside of our network when appropriate. We want to make sure all of your votes count!
Thanks for your participation in this important platform to help the IBD research community understand what research questions are important to patients. We are passionate about finding answers to your questions!
Examine the relation of Vitamin D deficiency possible contributing cause to IBD, beyond simple correlative data. Specifically Vit D involvement in immune development.
There is a well known increase in IBD in more western nations as well as higher latitudes. With most Western societies spending large amounts of time indoors at home, in cars, and at their employment, it's easy to see a causitive relation to decreased vitamin D in these populations. The increased latitude of Canada and Nordic countries also contributes low vitamin D levels in general population. Both of these population groups (Western Urban, and High latitudes) have increased incidence of IBD. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166406/ Provides a simple primer on Vit D relation to immune system development and maintenance; as well is it's deficiency in a host of autoimmune disorders. I would like to see a multi arm study along the following investigation paths: 1) Vit D testing for newly diagnosed. Followed by surveillance testing throughout treatment w/ and w/o vit supplementation arms. 2) Genetic testing for IBD markers/alleles in relation to Vit D levels (i.e. is the deficiency related to turning "on" various epigenetic and genetic markers that are present in active IBD). 3) Genetic testing of IBD markers, Vit D testing, and Gut microflora testing of non-active/IBD free family members for comparison of gene expression and interdependence between these factors, possibly prospective following of same patients if diagnosed offspring.
Do longitudinal evaluation of Vit D3 findings relate with disease activity, progress, treatment response, or remission?
Crohn's patients appear to have consistently low Vit D3, and disease prevalence is higher in northern latitudes with less sun and lower natural Vit D3 exposure and levels. Ultimately conduct longitudinal study to evaluate benefit aggressive management of Vit D3 to assist as adjunct in therapy, and to consider benefit of supplementation in at possible risk populations (1st degree family at high latitudes).
There is a significant population of patients for whom biologics are no longer a viable or recommended treatment. Our healthcare going forward is complicated by the permanent effects of these medications on the body's systems.
Develop non-invasive methods to remove hemorrhoids and perianal skin tags from IBD patients without the risk of ulcers, harm to sphincter, etc.
IBD patients are more much more likely to get hemorrhoids and skin tags (up to 37% of Crohn's and 25% of Colitis patients get skin tags - whereas only 4.4% of the general population gets hemorrhoids). But IBD patients either don't get them removed, or else risk significant harm in doing so. Innovative methods are needed to address the needs of this significant patient base.
How many IBD patients have ever been referred for counseling or offered an antidepressant by their gastroenterologist?
Depression and anxiety levels are very high in this population. Extending care to the whole person would make sense in managing disease and quality of life.
Prevalence and impact of inflammatory bowel disease-irritable bowel syndrome (IBD-IBS) on patient reported outcomes in CCFA Partners
The impact of ostomy on quality of life and functional status of Crohn's disease patients within CCFA Partners