In this area you will be able to:
- Propose, vote on, and discuss research ideas
- View current studies
- View published research
Here, you can submit a research idea to the community, cast your votes, and discuss research ideas proposed by other members. Please make your research question as specific as possible. Other members will vote on your research idea, and we will prioritize research ideas with the most votes.
You are allowed to vote for your own proposed research idea if you want. However, you can only vote for a total of five research ideas. If you have already cast your five votes and an idea you like even more is proposed, you can change your votes at any time to reflect your current preferences.
The research team will review all submitted ideas and provide a response to you and to the community. If your idea leads to an IBD Partners Study, you will have the opportunity to serve as a patient collaborator on the research team for that study.
We encourage you to prioritize the ideas that are most important to you, even if the research team determines that your idea is not a good fit for IBD Partners. We will share ideas labeled “Not a Good Fit” with researchers outside of our network when appropriate. We want to make sure all of your votes count!
Thanks for your participation in this important platform to help the IBD research community understand what research questions are important to patients. We are passionate about finding answers to your questions!
Can improving the diversity in the gut microbiome in UC patients by diet have an impact on reducing inflammation, improving symptoms, and mental health
Because we know that the microbiome of UC patients is different than healthy controls and in dysbiosis. Technologies are now available at much lower costs than years ago.
New research ive seen online indicates MAP could play a role in the cause of crohns. New research to detect and kill this bacteria may lead to a cure, better understanding, and better treatment for patients who are suffering from IBD.
Is the gut flora of people with IBD similar to people with depression and/or anxiety? I propose exploring a connection between the microbiota associated with IBD and mental health disorders.
I believe this question to be important because disruption of the gut flora is implicated in autoimmune diseases, obesity and mental illness and finding connections could broaden the medical community's approach in treating all of the above. I also think the designation of these illnesses as primarily "western illnesses" is interesting, particularly given how our food system functions (antibiotic use in meat production, use of bleach on salad greens, etc).
Since we know the Microbiome is a key component in Crohns disease, What therapies are being developed to treat the Microbiome?
I see drug companies producing drug after drug for inflammatory processes, which I know is needed for Crohns, but I am wondering when and if targeted Microbiome therapies are in the future of western medicine for Crohns?
Sequence the DNA of components of patients' microbiomes to find any associations with variables like severity of symptoms, location of disease, extra-intestinal manifestations and response to medications.
The 'genome' of a patient's microbiome could provide guidance in treating with specific medications and/or probiotics.
Use Next Generation Sequencing software developed by Charles Chiu, M.D. and associates at the University of California, San Francisco to see if any pathogens are associated with IBD.
This software can take blood or spinal fluid and compare 10 to 20 million DNA sequences against a database of all known pathogens.
Does the human microbiome affect the development of mastocytic enterocolitis in patients with inflammatory bowel disease?
My gastroenterologist and primary care doctor both suggest that they are seeing an increased number patients with IBD and mast cell colitis. As mastocytic enterocolitis is a relatively new diagnosis, there doesn't seem to be much information about causation yet.
Is the use of probiotics significantly beneficial for IBD patients? If so, what types are most beneficial for mucosal healing and prevention of future disease activity?
Current treatments for IBD focus heavily on the body's immune response and "warding off" the disease. It is important to do what we can to heal the intestine after damage has occurred and prevent damage to the best of our ability.
If the microbiome has impact on IBD, and the gut is colonized from the mother's flora, there should be differences in IBD inheritance between mothers vs. fathers and between vaginal vs. cesarean deliveries. Esp. in the case of children w/ IBD. Are there?
It seems easy to collect this data, and I think that if the microbiome is actually involved, these are logical hypotheses to test.
What is the role of antibiotics in triggering a flare up or induce/maintain remission (with particular focus on Rifaximin) ?
There have been a few researches showing that antibiotics might have a role in flares/remission. I have been diagnosed with UC 20 years ago and I have noticed that many times when I take antibiotics for other non IBD related issue my UC wakes up. I have also noticed that Rifaximin helps when I am experiencing mild symptoms. Could it be that some antibiotics kill the good bacteria therefore triggering a flare up and other have a positive effect killing the bad bacteria therefore supporting remission?