Research Ideas  

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Welcome to IBD Partners Research Ideas Page!

In this area you will be able to:

  • Propose, vote on, and discuss research ideas
  • View current studies
  • View published research

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You are an active participant in  IBD Partners research prioritization process! Have you ever had a question about IBD that you wish science could answer? Tell us what research is important to you!

Here, you can submit a research idea to the community, cast your votes, and discuss research ideas proposed by other members. Please make your research question as specific as possible. Other members will vote on your research idea, and we will prioritize research ideas with the most votes.

You are allowed to vote for your own proposed research idea if you want. However, you can only vote for a total of five research ideas. If you have already cast your five votes and an idea you like even more is proposed, you can change your votes at any time to reflect your current preferences.

The research team will review all submitted ideas and provide a response to you and to the community. If your idea leads to an IBD Partners Study, you will have the opportunity to serve as a patient collaborator on the research team for that study.

We encourage you to prioritize the ideas that are most important to you, even if the research team determines that your idea is not a good fit for IBD Partners. We will share ideas labeled “Not a Good Fit” with researchers outside of our network when appropriate. We want to make sure all of your votes count!

Thanks for your participation in this important platform to help the IBD research community understand what research questions are important to patients. We are passionate about finding answers to your questions!

Proposed Idea              

Since we know the Microbiome is a key component in Crohns disease, What therapies are being developed to treat the Microbiome?

I see drug companies producing drug after drug for inflammatory processes, which I know is needed for Crohns, but I am wondering when and if targeted Microbiome therapies are in the future of western medicine for Crohns?

Microbiome
last activity 10 months ago
1    1
Proposed Idea               Best Fit for Others

We should determine why the prevalence of IBD in developing countries is so low, yet immigrants from those countries and their children are at increased risk of IBD.

This question might help decipher the contribution of genetic and environmental factors (e.g. sunlight, the microbiome, exposure to antibiotics)

Environment
last activity over 1 year ago
43    1
Proposed Idea              

A recent study linked gut problems with food additives/emulsifiers such as polysorbate 80. Would anyone be interested in limiting their diet to prohibit food additives and emulsifiers that are in processed foods to see if it affects disease progression?

Increases in IBD seem to follow economic development, which includes the availability of more processed foods. It would make sense that food is involved with these diseases of the digestive system.

Diet
last activity over 1 year ago
9    2

I would like more research done on using the combination of a biologic (Humira) and Azathioprine (Imuran) together for treatment of crohns. Are the benefits really worth the risk? or is the risk not that bad?

I am on both of these meds and I have been questioned by my pharmacist about taking both of them together. I have read about the risks, and I'm not sure if I really do need both of the drugs. The information I have read seems to imply that getting cancer at some point is almost a certainty.

Medications
last activity over 1 year ago
7    4
Proposed Idea              

We need to find an effective way to properly detect our bodies food intolerance's.

Food is a major creator to our symptoms and without proper knowledge of what is upsetting our immune systems and causing our inflammation we will continue to suffer. I've currently been researching food intolerance tests and found as all things there are good and bad opinions towards the different food intolerance methods but in my reading I discovered many believe the tests are not entirely conclusive. If we created a test to easily determine the foods that cause us any irritation we would have a much better chance of going into remission by avoiding the foods that create inflammation.

Diet
last activity 12 months ago
41    0

How can the sCDAI be accurately assessed for Crohn's patients who experience constipation and not frequent and/or loose bowel movements?

Diarrhoea is not a symptom in all Crohn's patients. This causes two primary issues. The first issue is the length of time to be tested and diagnosed as constipation is not often seen as a symptom. Second, most disease activity surveys/charts/measurements become inaccurate for those who do not experience loose, watery stools. This only adds to the frustration and alienation of the patient from society and now their own IBD community.

Procedures And Testing
last activity almost 3 years ago
5    1
Proposed Idea              

Can fistulae (particularly perineal/perianal) be caused by holding in BMs for long stretches of time? Specifically, is this occurring in children and teens with IBD?

I had diarrhea from age 11 (1971) without a diagnosis until 1978 when I had a perineal abscess drained by a gynecologist in the hospital. I could see that it was a fistula (dad had medical books around the house). About a week later, while on Cleocin and Keflex, my colon perforated and I almost died before expl lap and temporary colostomy to "rest" my gut. I'd had 7 years of public school, holding in the stool all day, until I could get home. I was not comfortable having diarrhea at school, either because of complaints from kids or smokers who dominated the bathrooms.

Other
last activity almost 2 years ago
2    2
Proposed Idea              

Creation of a test to verify or deny IBD in persons struggling with symptoms

It took 16 years to verify my Cohn's, from age 13-29 years. Had all sorts of tests and was treated like I was crazy. Spent a month in treatment due to anorexia because eating was so painful. Diagnosed by having exploratory surgery. Because of that I had malnutrition, lost all my teeth and suffered way too long.

Procedures And Testing
last activity over 3 years ago
4    3

Can positive emotions favorably influence IBD patient status?

Research tends to focus on negative emotional state (depression) and the potential downside. Work by Dr B. Fredrickson shows positive emotions can provide favorable health impact and has developed a simple on line tool to measure positive emotions which could be incorporated into this site to do research going forward.

Other
last activity over 1 year ago
8    1
Microbiome
last activity 6 months ago
19    1

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Published Studies VIEW ALL
Diet Low in Red and Processed Meat Does Not Reduce Rate of Crohn’s Disease Flares

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Impact of Obesity on Disease Activity andPatient-Reported Outcomes Measurement InformationSystem (PROMIS) in Inflammatory Bowel Diseases

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A Novel Patient-Reported Outcome-Based Evaluation (PROBE) of Quality of Life in Patients With Inflammatory Bowel Disease

Read Study

Active Studies VIEW ALL
The Effects of Antidepressant Medication and Social Support on Disease Progression in IBD Patients

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Symptom Clusters in Adults with Inflammatory Bowel Disease

Read Study
Psychological Factors Associated with Adherence to Oral Treatment in IBD

Read Study

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