Research Ideas  

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Welcome to IBD Partners Research Ideas Page!

In this area you will be able to:

  • Propose, vote on, and discuss research ideas
  • View current studies
  • View published research

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You are an active participant in  IBD Partners research prioritization process! Have you ever had a question about IBD that you wish science could answer? Tell us what research is important to you!

Here, you can submit a research idea to the community, cast your votes, and discuss research ideas proposed by other members. Please make your research question as specific as possible. Other members will vote on your research idea, and we will prioritize research ideas with the most votes.

You are allowed to vote for your own proposed research idea if you want. However, you can only vote for a total of five research ideas. If you have already cast your five votes and an idea you like even more is proposed, you can change your votes at any time to reflect your current preferences.

The research team will review all submitted ideas and provide a response to you and to the community. If your idea leads to an IBD Partners Study, you will have the opportunity to serve as a patient collaborator on the research team for that study.

We encourage you to prioritize the ideas that are most important to you, even if the research team determines that your idea is not a good fit for IBD Partners. We will share ideas labeled “Not a Good Fit” with researchers outside of our network when appropriate. We want to make sure all of your votes count!

Thanks for your participation in this important platform to help the IBD research community understand what research questions are important to patients. We are passionate about finding answers to your questions!

Proposed Idea              

Effects of soluble and insoluble fiber on patients with Ulcerative Colitis vs Crohn's disease.

So many patients with IBD avoid high fiber foods for fear of exacerbating their symptoms. A previous CCFA Partners study "Avoidance of Fiber is Associated with Greater Risk of Crohn's Disease Flare in a 6 Month Period" addressed this, but unfortunately did not differentiate between soluble and insoluble fiber. There is not enough research on IBD and diet in general, but I believe it is so important, because we all have to eat. A high fiber diet is considered to be important for many aspects of good health in the general public. But insoluble fiber specifically is a part of the diet that is widely considered by IBD patients to be taboo. This thought is based on our own personal conclusions rather than on good, solid research. I want to know if and when it's safe to eat fruits and vegetables, and how to prepare them.

Diet
last activity 6 months ago
7    0
Proposed Idea              

Is there a correlation between the use of NSAIDS (Ibuprofen) or other medications known to cause a "leaky gut" and the onset/development of IBD?

I took a large amount of Ibuprofen throughout my teen years for migraines. I have been told that taking Ibuprofen now can cause me to come out of remission due to causing a leaky gut and so I am curious to see if these types of medications can cause or trigger the onset of IBD in adolescents or in patient who chronically take these forms of medications.

Medications
last activity about 1 year ago
5    0
Proposed Idea              

Is there a connection between insulin levels and development of IBD?

Many people seem to have less disease activity when they switch to a diet that restricts sugar, wheat or grains. Could there be a connection between high insulin levels (with or without diabetes)?

Diet
last activity 4 months ago
3    0
Proposed Idea              

Study the role that emulsifiers and other additives in our diet may play in IBD symptoms.

I am able to eat home made salad and salad dressing, but almost always get sick on a salad I eat out. Homemade bread, or bread from the chain of Great Harvest bakeries, causes me no problems, but packaged bread does. Rich homemade ice cream causes me no problems, but many packaged ice creams do. Making EVERYTHING from scratch, takes an enormous amount of time. Finding products without any emulsifiers or additives isn't easy; even simple ingredient lists of 5-7 items often contain at least 1. An understanding of even a few things known to be safer or less safe, would expand the repertoire of food I could eat. It's hard to personally test this with a food journal, because many products contain multiple additives. I know from facebook crohns forums, that I am not alone in these issues.

Diet
last activity 6 months ago
2    1

Did the Holocaust have to do with the rise in IBD?

We know that Jews of European decent have a much higher chance of having an IBD. We know that the number of diagnosis of IBD has risen significantly in the last few decades. What is the one huge event that happened to the Jews of Europe just 70 years ago? The Holocaust. It could be a gene that was associated with another gene that promoted survival. It could have been a gene mutation due to living in extreme conditions. It could have been the terrible sanitation. It could have been the trauma that had been passed on to the following generations... there is much to investigate there. I come from a family of Holocaust survivors, myself. Thank you for your consideration.

Genetics
last activity about 3 years ago
1    2
Proposed Idea              

Creation of a test to verify or deny IBD in persons struggling with symptoms

It took 16 years to verify my Cohn's, from age 13-29 years. Had all sorts of tests and was treated like I was crazy. Spent a month in treatment due to anorexia because eating was so painful. Diagnosed by having exploratory surgery. Because of that I had malnutrition, lost all my teeth and suffered way too long.

Procedures And Testing
last activity over 4 years ago
4    3

How can the sCDAI be accurately assessed for Crohn's patients who experience constipation and not frequent and/or loose bowel movements?

Diarrhoea is not a symptom in all Crohn's patients. This causes two primary issues. The first issue is the length of time to be tested and diagnosed as constipation is not often seen as a symptom. Second, most disease activity surveys/charts/measurements become inaccurate for those who do not experience loose, watery stools. This only adds to the frustration and alienation of the patient from society and now their own IBD community.

Procedures And Testing
last activity almost 4 years ago
5    1
Proposed Idea              

A recent study linked gut problems with food additives/emulsifiers such as polysorbate 80. Would anyone be interested in limiting their diet to prohibit food additives and emulsifiers that are in processed foods to see if it affects disease progression?

Increases in IBD seem to follow economic development, which includes the availability of more processed foods. It would make sense that food is involved with these diseases of the digestive system.

Diet
last activity over 2 years ago
9    2
Proposed Idea               Best Fit for Others

We should determine why the prevalence of IBD in developing countries is so low, yet immigrants from those countries and their children are at increased risk of IBD.

This question might help decipher the contribution of genetic and environmental factors (e.g. sunlight, the microbiome, exposure to antibiotics)

Environment
last activity over 2 years ago
43    1

Can positive emotions favorably influence IBD patient status?

Research tends to focus on negative emotional state (depression) and the potential downside. Work by Dr B. Fredrickson shows positive emotions can provide favorable health impact and has developed a simple on line tool to measure positive emotions which could be incorporated into this site to do research going forward.

Other
last activity over 2 years ago
8    1

Propose Research Idea


Published Studies VIEW ALL
Trends and Characteristics of Clinical Trials Participation for Inflammatory Bowel Disease in the United States: A Report From IBD Partners

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Diet Low in Red and Processed Meat Does Not Reduce Rate of Crohn’s Disease Flares

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Impact of Obesity on Disease Activity andPatient-Reported Outcomes Measurement InformationSystem (PROMIS) in Inflammatory Bowel Diseases

Read Study

Active Studies VIEW ALL
The Effects of Antidepressant Medication and Social Support on Disease Progression in IBD Patients

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Psychological Factors Associated with Adherence to Oral Treatment in IBD

Read Study
Rare IBD Characteristics Study

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