In this area you will be able to:
- Propose, vote on, and discuss research ideas
- View current studies
- View published research
Here, you can submit a research idea to the community, cast your votes, and discuss research ideas proposed by other members. Please make your research question as specific as possible. Other members will vote on your research idea, and we will prioritize research ideas with the most votes.
You are allowed to vote for your own proposed research idea if you want. However, you can only vote for a total of five research ideas. If you have already cast your five votes and an idea you like even more is proposed, you can change your votes at any time to reflect your current preferences.
The research team will review all submitted ideas and provide a response to you and to the community. If your idea leads to an IBD Partners Study, you will have the opportunity to serve as a patient collaborator on the research team for that study.
We encourage you to prioritize the ideas that are most important to you, even if the research team determines that your idea is not a good fit for IBD Partners. We will share ideas labeled “Not a Good Fit” with researchers outside of our network when appropriate. We want to make sure all of your votes count!
Thanks for your participation in this important platform to help the IBD research community understand what research questions are important to patients. We are passionate about finding answers to your questions!
Could virtual colonoscopy replace conventional colonoscopy as a routine method of assessment for patients in remission?
Virtual colonoscopy is less invasive, reducing the risk of bowel perforation and eliminating the need for anesthesia.
Examine the relation of Vitamin D deficiency possible contributing cause to IBD, beyond simple correlative data. Specifically Vit D involvement in immune development.
There is a well known increase in IBD in more western nations as well as higher latitudes. With most Western societies spending large amounts of time indoors at home, in cars, and at their employment, it's easy to see a causitive relation to decreased vitamin D in these populations. The increased latitude of Canada and Nordic countries also contributes low vitamin D levels in general population. Both of these population groups (Western Urban, and High latitudes) have increased incidence of IBD. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166406/ Provides a simple primer on Vit D relation to immune system development and maintenance; as well is it's deficiency in a host of autoimmune disorders. I would like to see a multi arm study along the following investigation paths: 1) Vit D testing for newly diagnosed. Followed by surveillance testing throughout treatment w/ and w/o vit supplementation arms. 2) Genetic testing for IBD markers/alleles in relation to Vit D levels (i.e. is the deficiency related to turning "on" various epigenetic and genetic markers that are present in active IBD). 3) Genetic testing of IBD markers, Vit D testing, and Gut microflora testing of non-active/IBD free family members for comparison of gene expression and interdependence between these factors, possibly prospective following of same patients if diagnosed offspring.
Compare medications taken (and other medical conditions experienced) by IBD patients BEFORE symptoms of IBD began to greater understand causes of the disease.
Prevention is the best medicine!
Do longitudinal evaluation of Vit D3 findings relate with disease activity, progress, treatment response, or remission?
Crohn's patients appear to have consistently low Vit D3, and disease prevalence is higher in northern latitudes with less sun and lower natural Vit D3 exposure and levels. Ultimately conduct longitudinal study to evaluate benefit aggressive management of Vit D3 to assist as adjunct in therapy, and to consider benefit of supplementation in at possible risk populations (1st degree family at high latitudes).
I have noticed significant changes to the number and viscosity of stool output based on Atmospheric Pressure (flying), Barometric Pressure (ground) and Humidity re CD and esp Colostomy ballooning. Friends w/IBS have also noticed such changes. I can submit 2 related articles via email (how?) for reference. Robert Huber, Scottsdale AZ 480.551.0520 Ostomy@AllCampusCard.com
Do changes in manufacturing processes of Biologics alter the clinical impact (treatment success and/or adverse events)?
Biologic medications are developed through a complex process of using living organisms to harvest the biologic proteins. Manufacturers sometimes alter the manufacturing process, and these changes have the potential to cause slight changes in the final product. There is a lack of data/research regarding the impact of these slight changes. Furthermore, biosimilars (biologics developed by new manufacturers with different manufacturing processes), are pending FDA approval. Biosimilars will not require as extensive clinical testing prior to approval, compared with the original manufactured products. We ought to collect extensive data to better understand if slight changes in biologic proteins have a clinical impact.
Why some women with Crohn's Disease achieve remission, during the second and third trimester of pregnancy, then flare months after giving birth.
Because, it happened to me with both of my.pregnancies. During my first trimester, I had to be hospitalized with partial obstruction. After that, I was healthier than I'd been in years, until a few months after giving birth.
Use Next Generation Sequencing software developed by Charles Chiu, M.D. and associates at the University of California, San Francisco to see if any pathogens are associated with IBD.
This software can take blood or spinal fluid and compare 10 to 20 million DNA sequences against a database of all known pathogens.
Develop a SPECIAL TAPE that will help hold the osty appliance on the skin when your out-put is very watery and there is gas involved and your stoma is sucking in!
I have had a very BIG problem of appliances blowing (2 to 4 times per day) when the stoma is sucking in and the out-put is watery and gas is involved. When this is happening and you are changing that much your skin is raw. You are burning through appliances left and right (cost). Not to mention your physiological well being!!
Impact of Obesity on Disease Activity andPatient-Reported Outcomes Measurement InformationSystem (PROMIS) in Inflammatory Bowel Diseases
A Novel Patient-Reported Outcome-Based Evaluation (PROBE) of Quality of Life in Patients With Inflammatory Bowel Disease